PERFLUOROKETONE COMPOUNDS AND USES THEREOF

Novel perfluoroketone compounds of formula [I] and [Ia] are described Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and / or inflammatory conditions, such as demeyelmat...

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Bibliographische Detailangaben
Hauptverfasser:	KOKOTOS, CHRISTOFOROS G, DAVID, SAMUEL, BASKAKIS, CONSTANTINOS, KOKOTOS, GEORGE, DENNIS, EDWARD A, KALYVAS, ATHENA, CONSTANTINOU-KOKOTOU, VIOLETTA, LOPEZ-VALES, RUBEN, STEPHENS, DAREN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel perfluoroketone compounds of formula [I] and [Ia] are described Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and / or inflammatory conditions, such as demeyelmatmg (e.g., multiple sclerosis) and neural injury (e.g., spinal cord injury). L'invention concerne de nouveaux composés de perfluorocétone. Elle concerne également leurs utilisations, par exemple, pour inhiber l'activité de phospholipase A2. Elle concerne également leurs utilisations thérapeutiques, par exemple, pour traiter des états neuraux et/ou inflammatoires, tels que la démyélinisation (par exemple, la sclérose en plaques) et la lésion neurale (par exemple, la lésion de la moëlle épinière).