AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS

AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS

The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles. La présente invention...

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Bibliographische Detailangaben
Hauptverfasser: MCDEVITT, ROBERT EMMETT, ROBICHAUD, ALBERT JEAN, KIM, JI-LN, SOLVIBILE, WILLIAM RONALD, MALAMAS, MICHAEL SOTIRIOS, PORTE, ALEXANDER MICHAEL, MORRIS, KOI MICHELE, ANTANE, SCHUYLER ADAM
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles. La présente invention concerne un composé 2-amino-5-[substitué-4-(difluorométhoxy)phényl]-5-phénylimidazolone de formule (I). La présente invention concerne également des procédés d'utilisation de celui-ci pour inhiber la b-sécrétase (BACE) et traiter des dépôts de b-amyloïde et des dégénérescences neurofibrillaires.