2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION

2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION

Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the...

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Bibliographische Detailangaben
Hauptverfasser: DAVE, BHAVESH, KAPKOTI, GOBIND, S, MOOKHTIAR, KASIM, A, BHUNIYA, DEBNATH, PALLE, VENKATA, P, CHUGH, ANITA, BASU, SUJAY, DE, SIDDARTHA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators. Les composés de la présente invention sont des dérivés d'acétamide 2,2,2-tri-substitué représentés par la formule (I), leurs polymorphes, stéréoisomères, promédicaments, solvates, des formulations et des sels pharmaceutiquement acceptables de ceux-ci, utiles en tant qu'activateur de la glucokinase. L'invention concerne également des procédés pour leur préparation. L'invention concerne en outre un procédé de caractérisation d'activateurs partiels de la glucokinase.