AGENT FOR SUPPRESSING REJECTION IN ORGAN TRANSPLANTATION COMPRISING ANTI-HMGB-1 ANTIBODY

Disclosed is a means which is effective for suppressing the rejection occurring in organ transplantation, particularly the rejection occurring in islet transplantation which is effective for the treatment of diabetes. It is found that an antibody directed against HMGB-1 can suppress the rejection oc...

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Bibliographische Detailangaben
Hauptverfasser:	YASUNAMI, YOHICHI, YAMADA, SHINGO, MARUYAMA, IKURO
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a means which is effective for suppressing the rejection occurring in organ transplantation, particularly the rejection occurring in islet transplantation which is effective for the treatment of diabetes. It is found that an antibody directed against HMGB-1 can suppress the rejection occurring in islet transplantation and can enhance the adhesion of the transplanted islet. Thus, disclosed is an agent for suppressing the rejection in organ transplantation, which comprises an anti-HMGB-1 antibody. L'invention concerne des moyens qui sont efficaces pour supprimer le rejet survenant lors d'une greffe d'organe, en particulier le rejet survenant lors d'une greffe d'îlots de Langerhans, greffe qui est efficace pour le traitement du diabète. Il a été trouvé qu'un anticorps dirigé contre HMGB-1 pouvait supprimer le rejet survenant lors de la greffe d'îlots de Langerhans et pouvait accroître l'adhésion des îlots de Langerhans greffés. Ainsi, l'invention concerne un agent servant à supprimer le rejet lors d'une greffe d'organe, lequel comprend un anticorps anti-HMGB-1.