METHOD AND SUBSTANCES FOR TREATING HPV INFECTION

The present invention is directed to novel polypeptides and compositions capable of binding to the E6 oncoprotein of human papillomavirus (HPV), and to methods of employing the novel polypeptides and compositions of the invention to treat HPV infection. In one aspect, the invention is directed to ex...

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Bibliographische Detailangaben
Hauptverfasser:	TUNGTEAKKHUN, SANDY, S, FILIPPOVA, MARIA, NEIDIGH, JONATHAN, W, DUERKSEN-HUGHES, PENELOPE, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to novel polypeptides and compositions capable of binding to the E6 oncoprotein of human papillomavirus (HPV), and to methods of employing the novel polypeptides and compositions of the invention to treat HPV infection. In one aspect, the invention is directed to expression vectors encoding the polypeptides, which contain an E6-binding domain derived from a fragment of FADD, and to host cells containing the vectors. La présente invention concerne de nouveaux polypeptides et compositions capables de se lier à l'oncoprotéine E6 du papillomavirus humain (VPH) et des procédés d'emploi des nouveaux polypeptides et compositions de l'invention pour traiter une infection par le VPH. Sous un aspect, l'invention concerne des vecteurs d'expression codant les polypeptides, qui contiennent un domaine de liaison E6 dérivé d'un fragment FADD, et des cellules hôtes contenant les vecteurs.