ANIMAL HAVING MODIFICATION IN MGAT2 GENE

[PROBLEMS] To provide: a gene-modified non-human animal having inactivated MGAT2 gene, which is useful for the search of the function of MGAT2 in vivo; a gene-modified non-human animal cell; a method for screening of a compound capable of inhibiting the activity of MGAT2; a compound capable of inhib...

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Bibliographische Detailangaben
Hauptverfasser:	ITO, YOSHIKI, OHBUCHI, KATSUYA, TAMAI, YOSHITAKA, TOKUSHIMA, YUKINA, KUSUNOKI, JUN, MARUYAMA, TAKAHARU, MURAI, NAOMI, ARAGANE, KATSUYA, HARADA, NAOMOTO
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	[PROBLEMS] To provide: a gene-modified non-human animal having inactivated MGAT2 gene, which is useful for the search of the function of MGAT2 in vivo; a gene-modified non-human animal cell; a method for screening of a compound capable of inhibiting the activity of MGAT2; a compound capable of inhibiting the activity of MGAT2; and a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene; and a method for screening of a compound by using the mammal. The mammal and the method enable to prevent or treat a disease induced by abnormal lipid metabolism. Also disclosed is the screening of a compound capable of inhibiting or enhancing the function of MAGT2. The screening enables to prevent or treat a disease induced by abnormal lipid metabolism. [PROBLEMES] Etant donné un animal non humain génétiquement modifié ayant un gène MGAT2 inactivé, qui est utile pour la recherche de la fonction du MGAT2 in vivo ; une cellule animale non humaine génétiquement modifiée ; un procédé d'analyse d'un composé capable d'inhiber l'activité du MGAT2; ; et un procédé pour détecter une maladie induite par un métabolisme lipidique anormal basé sur le niveau d'expression ou l'activité du MGAT2. [MOYENS DE RESOUDRE LES PROBLEMES] Nous divulguons un mammifère non humain génétiquement modifié présentant l'expression artificiellement inhibée du gène MGAT2 ; et un procédé d'analyse d'un composé en utilisant le mammifère. Le mammifère et le procédé permettent d'empêcher ou de traiter une maladie induite par un métabolisme lipidique anormal. Est également divulguée l'analyse d'un compose capable d'inhiber ou d'améliorer la fonction du MAGT2. L'analyse permet d'empêcher ou de traiter une maladie induite par un métabolisme lipidique anormal.