DEACYLATION OF SUCRALOSE-6-ACYLATES

A method of making sucralose includes maintaining a solution of a sucralose-6- acylate in an aqueous solvent at a temperature in a range from -20°C to 20°C and at a pH of at least 12.2 and less than 14.0 for a period of time sufficient to deacylate substantially all of the sucralose-6-acylate. The m...

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Hauptverfasser:	LEINHOS, DUANE A, WILEY, JR., JAMES EDWIN, DENTEL, DAVID A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SUGARS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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creator	LEINHOS, DUANE A WILEY, JR., JAMES EDWIN DENTEL, DAVID A
description	A method of making sucralose includes maintaining a solution of a sucralose-6- acylate in an aqueous solvent at a temperature in a range from -20°C to 20°C and at a pH of at least 12.2 and less than 14.0 for a period of time sufficient to deacylate substantially all of the sucralose-6-acylate. The method may employ purified sucralose-6-acylate as the starting material, or the sucralose-6-acylate may be present in a quenched reaction mixture resulting from chlorination of a sucrose-6-acylate. The quenched reaction mixture may be exposed to deacylation conditions either before or after removal of a tertiary amide that may be present in it. Sucralose is subsequently recovered to complete the process. Procédé d'élaboration de sucralose, consistant à maintenir une solution de sucralose-6- acylate dans un solvant aqueux à une température comprise entre -20°C et 20°C et à un pH d'au moins 12,2 et inférieur à 14 pendant une durée suffisante pour la désacylation de sensiblement la totalité du sucralose-6-acylate. On peut utiliser à cet effet du sucralose-6-acylate purifié comme matériau de départ, ou bien le sucralose-6-acylate peut être présent dans un mélange réactif bloqué résultant de la chloruration d'un sucralose-6-acylate. Ledit mélange peut être soumis à des conditions de désacylation avant ou après l'élimination d'un amide tertiaire qui peut s'y trouver. On récupère ensuite le sucralose pour boucler le processus.
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The method may employ purified sucralose-6-acylate as the starting material, or the sucralose-6-acylate may be present in a quenched reaction mixture resulting from chlorination of a sucrose-6-acylate. The quenched reaction mixture may be exposed to deacylation conditions either before or after removal of a tertiary amide that may be present in it. Sucralose is subsequently recovered to complete the process. Procédé d'élaboration de sucralose, consistant à maintenir une solution de sucralose-6- acylate dans un solvant aqueux à une température comprise entre -20°C et 20°C et à un pH d'au moins 12,2 et inférieur à 14 pendant une durée suffisante pour la désacylation de sensiblement la totalité du sucralose-6-acylate. On peut utiliser à cet effet du sucralose-6-acylate purifié comme matériau de départ, ou bien le sucralose-6-acylate peut être présent dans un mélange réactif bloqué résultant de la chloruration d'un sucralose-6-acylate. 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The method may employ purified sucralose-6-acylate as the starting material, or the sucralose-6-acylate may be present in a quenched reaction mixture resulting from chlorination of a sucrose-6-acylate. The quenched reaction mixture may be exposed to deacylation conditions either before or after removal of a tertiary amide that may be present in it. Sucralose is subsequently recovered to complete the process. Procédé d'élaboration de sucralose, consistant à maintenir une solution de sucralose-6- acylate dans un solvant aqueux à une température comprise entre -20°C et 20°C et à un pH d'au moins 12,2 et inférieur à 14 pendant une durée suffisante pour la désacylation de sensiblement la totalité du sucralose-6-acylate. On peut utiliser à cet effet du sucralose-6-acylate purifié comme matériau de départ, ou bien le sucralose-6-acylate peut être présent dans un mélange réactif bloqué résultant de la chloruration d'un sucralose-6-acylate. 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The method may employ purified sucralose-6-acylate as the starting material, or the sucralose-6-acylate may be present in a quenched reaction mixture resulting from chlorination of a sucrose-6-acylate. The quenched reaction mixture may be exposed to deacylation conditions either before or after removal of a tertiary amide that may be present in it. Sucralose is subsequently recovered to complete the process. Procédé d'élaboration de sucralose, consistant à maintenir une solution de sucralose-6- acylate dans un solvant aqueux à une température comprise entre -20°C et 20°C et à un pH d'au moins 12,2 et inférieur à 14 pendant une durée suffisante pour la désacylation de sensiblement la totalité du sucralose-6-acylate. On peut utiliser à cet effet du sucralose-6-acylate purifié comme matériau de départ, ou bien le sucralose-6-acylate peut être présent dans un mélange réactif bloqué résultant de la chloruration d'un sucralose-6-acylate. Ledit mélange peut être soumis à des conditions de désacylation avant ou après l'élimination d'un amide tertiaire qui peut s'y trouver. On récupère ensuite le sucralose pour boucler le processus.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY DERIVATIVES THEREOF FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SUGARS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
title	DEACYLATION OF SUCRALOSE-6-ACYLATES
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