N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES

The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of...

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Bibliographische Detailangaben
Hauptverfasser:	POWERS, JAY, HAN, NIANHE, LIU, QINGYIAN, YUAN, CHESTER, C, MCMINN, DUSTIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11ß-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions. L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11ß-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases.