PROCESS FOR THE SYNTHESIS OF N9-(3,5-DICHLORO-4-PYRIDYL)-6- DIFLUOROMETHOXYBENZO(4,5)FURO(3,2-C)PYRIDINE-9-CARBOXAMIDE AND SALTS THEREOF

PROCESS FOR THE SYNTHESIS OF N9-(3,5-DICHLORO-4-PYRIDYL)-6- DIFLUOROMETHOXYBENZO(4,5)FURO(3,2-C)PYRIDINE-9-CARBOXAMIDE AND SALTS THEREOF

The present invention relates to a process for the synthesis of N9-(3,5- dichloro-4-pyridyl)-6-difluoromethoxybenzo[4,5]furo[3,2-c]pyridine-9-carboxamide and salts thereof which are useful as a PDE4 inhibitor. The invention also relates to a process for the synthesis of methyl-2-formyl-7-cyclopentyl...

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Bibliographische Detailangaben
Hauptverfasser: BHADANE, SHAILENDRA, KADAM, SURESH, M, GHARAT, LAXMIKANT ATMARAM, GAJERA, JITENDRA, MAGANBHAI, FARANDE, ANIKET, VIJAYKUMAR, CHAPALA, KASTURAIAH
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention relates to a process for the synthesis of N9-(3,5- dichloro-4-pyridyl)-6-difluoromethoxybenzo[4,5]furo[3,2-c]pyridine-9-carboxamide and salts thereof which are useful as a PDE4 inhibitor. The invention also relates to a process for the synthesis of methyl-2-formyl-7-cyclopentyloxybenzo[b]furan-4-carboxylate and salts thereof, which are useful as intermediates in preparing compounds with PDE4 inhibitory activity. La présente invention porte sur un procédé pour la synthèse de N9-(3,5-dichloro-4-pyridyl)-6-difluorométhoxybenzo[4,5]furo[3,2-c]pyridine-9-carboxamide et sur leurs sels, qui sont utiles comme inhibiteurs de PDE4. L'invention porte également sur un procédé pour la synthèse de 2-formyl-7-cyclopentyloxybenzo[b]furan-4-carboxylate de méthyle et sur ses sels, qui sont utiles comme intermédiaires dans la préparation de composés présentant une activité inhibitrice de PDE4.