QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. Cette invention concerne de nouveaux composés qui sont des i...

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Bibliographische Detailangaben
Hauptverfasser:	RAMURTHY, SAVITHRI, WARNE, ROBERT, L, ZHOU, YASHEEN, LIN, XIAODONG, SUBRAMANIAN, SHARADA, MURRAY, JEREMY, M, BASHAM, STEVEN, E, WANG, XIAOJING, M, RICO, ALICE, C, DOVE, JEFFREY, AIKAWA, MINA, AMIRI, PAYMAN, JAIN, RAMA, SHU, WEI
Format:	Patent
Sprache:	eng ; fre
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. Cette invention concerne de nouveaux composés qui sont des inhibiteurs de PDK1. Elle concerne également des compositions pharmaceutiques contenant ces composés, et des méthodes utilisant ces composés et compositions pour le traitement de maladies à évolution chronique comme le cancer.