METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS

Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells. A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treate...

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Bibliographische Detailangaben
Hauptverfasser:	STOVER, DAVID RAYMOND, LI, JING
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells. A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with: an Anti-DR5 antibody agonists; and one or more pharmaceutically active agents. Cette invention concerne des agonistes des anticorps anti-DR4 ou anti-DR5, associés avec des agents inducteurs d'apoptose, induisant en synergie l'apoptose des cellules cancéreuses. L'invention concerne également un traitement combiné permettant de traiter les patients souffrant de maladies prolifératives ou de maladies associées avec une angiogenèse persistante. Le patient reçoit le traitement suivant : un agoniste de l'anticorps anti-DR5, et un ou plusieurs agents pharmaceutiquement actifs.