RAPID DETECTION OF CHOLINESTERASE INHIBITORS

The present invention relates to a rapid, high-throughput detection method for screening of potential casualties exposed to a cholinesterase inhibitor. A kit is provided for conducting the method that requires only a small volume of sample such as blood for detection and has a rapid screening throug...

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Bibliographische Detailangaben
Hauptverfasser:	SEOW, JOSEFINA, TAN, YONG TENG, LOKE, WENG KEONG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a rapid, high-throughput detection method for screening of potential casualties exposed to a cholinesterase inhibitor. A kit is provided for conducting the method that requires only a small volume of sample such as blood for detection and has a rapid screening throughput for multiple casualties. The kit is able to detect both free and protein-bound- cholinesterase inhibitors. The method should be able to differentiate asymptomatic exposure from the mass psychogenic illness cases. La présente invention concerne un procédé de détection rapide et à haut rendement permettant le dépistage de personnes susceptibles d'être victimes d'une exposition à un inhibiteur de cholinestérase. La trousse permettant la mise en oevre du procédé selon l'invention ne requiert qu'un petit volume d'échantillon, tel que du sang, pour la détection et présente une capacité de dépistage rapide d'un grand nombre de victimes. La trousse donne la possibilité de détecter des inhibiteurs de cholinestérase tant libres que liés à des protéines. Le procédé devrait permettre de différencier une exposition asymptomatique des cas de maladie psychogène de masse.