INDOLE SULFONAMIDES AS SFRP-1 MODULATORS

Indole sulfonamide compounds or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis. (I) R1 is alkyl, perflu...

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Bibliographische Detailangaben
Hauptverfasser:	KERN, JEFFREY, CURTIS, TRYBULSKI, EUGENE, JOHN, WELMAKER, GREGORY, SCOTT, WILSON, MATTHEW, ALAN, MOORE, WILLIAM, JAY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Indole sulfonamide compounds or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis. (I) R1 is alkyl, perfluoroalkyl, halo, cyano, or CO2alkyl; R2 is optionally substituted alkyl, cycloalkyl, heterocycloalkyl, or spiroheterocycloalkyl; R3 is optionally substituted aryl. R4 is optionally substituted alkyl, cycloalkyl, or heterocycloalkyl; R5 is hydrogen or alkyl; R6 is optionally substituted aryl or heteroaryl; R7 is alkyl, perfluoroalkyl, halo, cyano, or alkoxycarbonyl; and X is absent or SO2. L'invention concerne des composés de sulfamides d'indole ou des sels pharmaceutiquement acceptables de ceux-ci, qui sont des modulateurs de la protéine 1 SFRP (secreted frizzled related protein). Les composés et les compositions contenant les composés peuvent être utilisés pour traiter divers troubles comprenant l'ostéoporose.