CRYSTALLINE COMPOSITION OF GM-CSF/GM-CSFR

The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony stimulating factor (GM-CSF) and its receptor (GM-CSFR). The present invention further provides methods for t...

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Bibliographische Detailangaben
Hauptverfasser:	PARKER, MICHAEL, WILLIAM, HERCUS, TIMOTHY, ROBERT, LOPEZ, ANGEL, FRANCISCO, MCKINSTRY, WILLIAM, JOHN, HANSEN, GUIDO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CALCULATING CHEMISTRY COMPUTING COUNTING DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR TESTING
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Beschreibung
Zusammenfassung:	The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony stimulating factor (GM-CSF) and its receptor (GM-CSFR). The present invention further provides methods for the design and selection of modulators of GM-CSF/GM-CSFR interaction and signaling as well as signaling of other cytokines. La présente invention concerne de manière générale le domaine de la cristallographie. La présente invention concerne plus particulièrement des formes cristallines d'un complexe entre le facteur de stimulation de la formation de colonies granulo-macrophagiques (GM-CSF) et son récepteur (GM-CSFR). La présente invention concerne également des procédés de conception et de sélection de modulateurs de l'interaction et du signalement GM-CSF/GM-CSFR, ainsi que du signalement d'autres cytokines.