MEDICAL DEVICE INCLUDING A BIOACTIVE IN A NON-IONIC AND AN IONIC FORM AND METHODS OF PREPARATION THEREOF

A medical device having a bioactive in a salt and a free-base form contained within the device and/or coated onto a surface of the device. The salt and the free-base form have different solubilities in an aqueous medium. The elution of bioactive from the device in an aqueous medium is tailored by fi...

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Bibliographische Detailangaben
Hauptverfasser:	JOHNSON, MICHAEL, T.V, ALEGRIA, LARRY, A, LUCHSINGER, BENJAMIN, P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Beschreibung
Zusammenfassung:	A medical device having a bioactive in a salt and a free-base form contained within the device and/or coated onto a surface of the device. The salt and the free-base form have different solubilities in an aqueous medium. The elution of bioactive from the device in an aqueous medium is tailored by fixing the ratio of forms. Methods of preparing such a device are also provided. L'invention concerne un dispositif médical contenant un agent bioactif ou dont une surface est revêtue d'un agent bioactif sous forme de sel et de base libre, chaque forme présentant des solubilités différentes en milieu aqueux. L'élution de l'agent bioactif du dispositif dans un milieu aqueux est personnalisée en fixant le rapport de formes. L'invention propose également des procédés de préparation d'un tel dispositif.