PROCESSES FOR THE PREPARATION OF 7-SUBSTITUTED 3,3-DIMETHYL-4-AMINO-PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES

The present invention relates to process for the preparation of racemic and optically pure enantiomers of 1-cyclopropyl-6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1-yl)-4- oxo-l,4-dihydro-quinolin-3-carboxylic acid and salts thereof. The present invention also provides novel crystalline for...

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Bibliographische Detailangaben
Hauptverfasser:	DESHPANDE, PRASAD, KESHAV, BHAVSAR, SATISH, BALIRAM, JOSHI, SANJEEV, NARHARI, KALE, RAJESH, PRABHAKAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The present invention relates to process for the preparation of racemic and optically pure enantiomers of 1-cyclopropyl-6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1-yl)-4- oxo-l,4-dihydro-quinolin-3-carboxylic acid and salts thereof. The present invention also provides novel crystalline forms of racemic and optically pure enantiomers of 1-cyclopropyl- 6-fluoro-8-methyl-7-(4-amino-3,3-dimethyl-piperidin-1 -yl)-4-oxo-1,4-dihydro-quinolin-3- carboxylic acid hydrochloride and compositions containing polymorphs. The present invention further provides pure (RS)-(±)-4-amino-3,3-dimethyl-piperidine and pure (R) or (S)-enantiomers of 4-amino-3,3-dimethyl-piperidine compounds. La présente invention concerne un procédé destiné à la préparation d'énantiomères racémiques et optiquement purs d'acide 1-cyclopropyl-6-fluoro-8-méthyl-7-(4-amino-3,3-diméthyl-pipéridin-1-yl)-4- oxo-1,4-dihydro-quinolin-3-carboxylique et de leurs sels. La présente invention concerne également de nouvelles formes cristallines d'énantiomères racémiques et optiquement purs de chlorhydrate d'acide 1-cyclopropyl-6-fluoro-8-méthyl-7-(4-amino-3,3-diméthyl-pipéridin-1-yl)-4- oxo-1,4-dihydro-quinolin-3-carboxylique et des compositions contenant des polymorphes. La présente invention concerne également une (RS)-(±)-4-amino-3,3-diméthyl-pipéridine et des énantiomères (R) ou (S) purs de composés de 4-amino-3,3-diméthyl-pipéridine.