KINASE INHIBITORS, AND METHODS OF USING AND IDENTIFYING KINASE INHIBITORS

KINASE INHIBITORS, AND METHODS OF USING AND IDENTIFYING KINASE INHIBITORS

Methods of inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, methods of treating patients by inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, chemical entities that bind to BTK and inhibited complexes are provided. La présente invention concerne des procédés...

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Hauptverfasser: PIPPEN, DOUGLAS A.I, GALLION, STEVEN L, BRITELLI, DAVID R, KROPF, JEFFREY E, MITCHELL, SCOTT A, WHITNEY, JAMES A, CURRIE, KEVIN S, DI PAOLO, JULIE, VALLECA, MARK A, STAFFORD, DOUGLAS GREGORY, BLOMGREN, PETER A, DARROW, JAMES W, LEE, TONY
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Methods of inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, methods of treating patients by inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, chemical entities that bind to BTK and inhibited complexes are provided. La présente invention concerne des procédés d'inhibition d'une activité BTK par l'inhibition de la phosphorylation du Y551 de la BTK, des procédés de traitement de patients en inhibant une activité BTK par l'inhibition de la phosphorylation du Y551 de la BTK, des entités chimiques qui se lient à la BTK et des complexes inhibés.