VINYL PHOSPHONATE LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

The present invention provides LPA analogs that are antagonists at the LPA receptors. The analogs have the formula (I) wherein Z is -CY=CH- or -G=C-; wherein when Z is -CY=CH- then the double bond is in the trans (e) configuration; Y is hydrogen or halogen, and R1-R° and m and n are as defined in th...

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Bibliographische Detailangaben
Hauptverfasser:	CARTER, KAREN, M, MACDONALD, TIMOTHY, L, LYNCH, KEVIN, R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides LPA analogs that are antagonists at the LPA receptors. The analogs have the formula (I) wherein Z is -CY=CH- or -G=C-; wherein when Z is -CY=CH- then the double bond is in the trans (e) configuration; Y is hydrogen or halogen, and R1-R° and m and n are as defined in the application. La présente invention concerne des analogues de LPA qui sont des antagonistes des récepteurs LPA.