AN OXIDATION PROCESS FOR THE PREPARATION OF N-[3-AMINO-1- (CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-{N-[(TERT-BUTYLAMINO)CARBONYL]-3-METHYL-L-VALYL}-6,6-DIMETHYL-3-AZABICYCLO[3.1.0] HEXANE-2-CARBOXAMIDE AND RELATED COMPOUNDS

AN OXIDATION PROCESS FOR THE PREPARATION OF N-[3-AMINO-1- (CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-{N-[(TERT-BUTYLAMINO)CARBONYL]-3-METHYL-L-VALYL}-6,6-DIMETHYL-3-AZABICYCLO[3.1.0] HEXANE-2-CARBOXAMIDE AND RELATED COMPOUNDS

The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I. La pré...

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Bibliographische Detailangaben
Hauptverfasser: WU, GEORGE, G, XIE, JI, CHEN, FRANK, XING, POIRIER, MARC, SPRAGUE, VICTORIA, M, RASHATASAKHON, PAITOON
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I. La présente demande de brevet concerne un procédé de préparation d'un composé selon la formule I : où R1 est alkyle ; R2 est alkyle ; et R3 est éventuellement cycloalklylalkyle substitué, le procédé consistant à oxyder un composé selon la formule dans laquelle R1, R2 et R3 sont définis ci-dessus afin de produire un composé selon la formule I.