METHOD FOR OBTAINING AND ANALYZING SOLIDS, PREFERABLY CRYSTALS
The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: - providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being...
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Zusammenfassung: | The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: - providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being provided with a filter having pores, which filter is arranged at a distance below the open upper end, each of the wells having an upper inner wall part above the filter that has a fluid contact surface and each filter having a top filter surface, at least both the fluid contact surface of the well and the top filter surface being of a material that is at least substantially inert for organic and/or aqueous solvents and/or mixtures of organic and aqueous solvents. - providing one or more substances and one or more solvents in at least one of the wells of the well plate, - applying conditions to dissolve the one or more substances in the one or more solvents; - applying conditions for crystallizing at least a part of the substance so that solids are formed in the at least one well, - substantially removing the part of the substance that remains in solution, thereby leaving the solids, preferably crystals, that were formed from the substance in the well of the well plate in which they were formed, - performing further investigation of the solids, preferably crystals in the well of the well plate where they were formed.
La présente invention concerne un procédé permettant d'obtenir et d'analyser des solides, de préférence des cristaux, lequel procédé comprend les étapes suivantes : - fourniture d'une plaque de puits, la plaque de puits comprenant une pluralité de puits, chacun des puits ayant une profondeur et une extrémité supérieure ouverte, et chacun des puits étant pourvu d'un filtre présentant des pores, lequel filtre est disposé à une certaine distance sous l'extrémité supérieure ouverte, chacun des puits présentant une partie de paroi interne supérieure au-dessus du filtre possédant une surface de contact de fluide et chaque filtre présentant une surface filtrante supérieure, au moins à la fois la surface de contact de fluide du puits et la surface filtrante supérieure étant constituées d'un matériau qui est au moins sensiblement inerte pour les solvants organiques et/ou aqueux et/ou les mélanges de solvants organiques et aqueux, - fourniture d'une ou plusieurs substances et d'un ou plusieurs solvants dans au moins l'un des puits de la plaque de puits, - app |
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