STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN

The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the cl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LOU, MEIZHEN, SPARROW, LINDSAY, GALE, LOVRECZ, GEORGE, MCKERN, NEIL, MORETON, WARD, COLIN, WESLEY, GARRETT, THOMAS, P., J, ADAMS, TIMOTHY, EDWARD, STRELSTOV, VICTOR, LAWRENCE, MICHAEL, COLIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CALCULATING CHEMISTRY COMBINATORIAL CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	LOU, MEIZHEN SPARROW, LINDSAY, GALE LOVRECZ, GEORGE MCKERN, NEIL, MORETON WARD, COLIN, WESLEY GARRETT, THOMAS, P., J ADAMS, TIMOTHY, EDWARD STRELSTOV, VICTOR LAWRENCE, MICHAEL, COLIN
description	The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof. La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2007147213A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2007147213A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2007147213A13</originalsourceid><addsrcrecordid>eNrjZNAJDgkKdQ4JDXJV8HdTCPFwVfD0Cw718fRTCHJ1dg0I8Q9ScHUO8Xfx93X09ONhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGBuaGJuZGhsaOhsbEqQIARvomSQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN</title><source>esp@cenet</source><creator>LOU, MEIZHEN ; SPARROW, LINDSAY, GALE ; LOVRECZ, GEORGE ; MCKERN, NEIL, MORETON ; WARD, COLIN, WESLEY ; GARRETT, THOMAS, P., J ; ADAMS, TIMOTHY, EDWARD ; STRELSTOV, VICTOR ; LAWRENCE, MICHAEL, COLIN</creator><creatorcontrib>LOU, MEIZHEN ; SPARROW, LINDSAY, GALE ; LOVRECZ, GEORGE ; MCKERN, NEIL, MORETON ; WARD, COLIN, WESLEY ; GARRETT, THOMAS, P., J ; ADAMS, TIMOTHY, EDWARD ; STRELSTOV, VICTOR ; LAWRENCE, MICHAEL, COLIN</creatorcontrib><description>The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof. La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.</description><language>eng ; fre</language><subject>CALCULATING ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPUTING ; COUNTING ; ELECTRIC DIGITAL DATA PROCESSING ; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; TESTING</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071227&DB=EPODOC&CC=WO&NR=2007147213A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071227&DB=EPODOC&CC=WO&NR=2007147213A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOU, MEIZHEN</creatorcontrib><creatorcontrib>SPARROW, LINDSAY, GALE</creatorcontrib><creatorcontrib>LOVRECZ, GEORGE</creatorcontrib><creatorcontrib>MCKERN, NEIL, MORETON</creatorcontrib><creatorcontrib>WARD, COLIN, WESLEY</creatorcontrib><creatorcontrib>GARRETT, THOMAS, P., J</creatorcontrib><creatorcontrib>ADAMS, TIMOTHY, EDWARD</creatorcontrib><creatorcontrib>STRELSTOV, VICTOR</creatorcontrib><creatorcontrib>LAWRENCE, MICHAEL, COLIN</creatorcontrib><title>STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN</title><description>The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof. La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.</description><subject>CALCULATING</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPUTING</subject><subject>COUNTING</subject><subject>ELECTRIC DIGITAL DATA PROCESSING</subject><subject>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJDgkKdQ4JDXJV8HdTCPFwVfD0Cw718fRTCHJ1dg0I8Q9ScHUO8Xfx93X09ONhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGBuaGJuZGhsaOhsbEqQIARvomSQ</recordid><startdate>20071227</startdate><enddate>20071227</enddate><creator>LOU, MEIZHEN</creator><creator>SPARROW, LINDSAY, GALE</creator><creator>LOVRECZ, GEORGE</creator><creator>MCKERN, NEIL, MORETON</creator><creator>WARD, COLIN, WESLEY</creator><creator>GARRETT, THOMAS, P., J</creator><creator>ADAMS, TIMOTHY, EDWARD</creator><creator>STRELSTOV, VICTOR</creator><creator>LAWRENCE, MICHAEL, COLIN</creator><scope>EVB</scope></search><sort><creationdate>20071227</creationdate><title>STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN</title><author>LOU, MEIZHEN ; SPARROW, LINDSAY, GALE ; LOVRECZ, GEORGE ; MCKERN, NEIL, MORETON ; WARD, COLIN, WESLEY ; GARRETT, THOMAS, P., J ; ADAMS, TIMOTHY, EDWARD ; STRELSTOV, VICTOR ; LAWRENCE, MICHAEL, COLIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007147213A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CALCULATING</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPUTING</topic><topic>COUNTING</topic><topic>ELECTRIC DIGITAL DATA PROCESSING</topic><topic>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LOU, MEIZHEN</creatorcontrib><creatorcontrib>SPARROW, LINDSAY, GALE</creatorcontrib><creatorcontrib>LOVRECZ, GEORGE</creatorcontrib><creatorcontrib>MCKERN, NEIL, MORETON</creatorcontrib><creatorcontrib>WARD, COLIN, WESLEY</creatorcontrib><creatorcontrib>GARRETT, THOMAS, P., J</creatorcontrib><creatorcontrib>ADAMS, TIMOTHY, EDWARD</creatorcontrib><creatorcontrib>STRELSTOV, VICTOR</creatorcontrib><creatorcontrib>LAWRENCE, MICHAEL, COLIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LOU, MEIZHEN</au><au>SPARROW, LINDSAY, GALE</au><au>LOVRECZ, GEORGE</au><au>MCKERN, NEIL, MORETON</au><au>WARD, COLIN, WESLEY</au><au>GARRETT, THOMAS, P., J</au><au>ADAMS, TIMOTHY, EDWARD</au><au>STRELSTOV, VICTOR</au><au>LAWRENCE, MICHAEL, COLIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN</title><date>2007-12-27</date><risdate>2007</risdate><abstract>The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof. La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng ; fre
recordid	cdi_epo_espacenet_WO2007147213A1
source	esp@cenet
subjects	CALCULATING CHEMISTRY COMBINATORIAL CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
title	STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T17%3A14%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LOU,%20MEIZHEN&rft.date=2007-12-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2007147213A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true