STRUCTURE OF THE INSULIN RECEPTOR ECTODOMAIN

The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the cl...

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Bibliographische Detailangaben
Hauptverfasser:	LOU, MEIZHEN, SPARROW, LINDSAY, GALE, LOVRECZ, GEORGE, MCKERN, NEIL, MORETON, WARD, COLIN, WESLEY, GARRETT, THOMAS, P., J, ADAMS, TIMOTHY, EDWARD, STRELSTOV, VICTOR, LAWRENCE, MICHAEL, COLIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CALCULATING CHEMISTRY COMBINATORIAL CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof. La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.