AN ASSAY FOR MODULATORS OF APOPTOSIS

The present invention relates generally to an assay for molecules which modulate apoptosis, to molecules identified by the assay and to use of the molecules. More particularly, an assay is provided for screening for molecules that interact with and which antagonize or agonize the anti-apoptotic prop...

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Bibliographische Detailangaben
Hauptverfasser:	COLMAN, PETER MALCOLM, HUANG, DAVID CHING SIANG, CZABOTAR, PETER EDWARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates generally to an assay for molecules which modulate apoptosis, to molecules identified by the assay and to use of the molecules. More particularly, an assay is provided for screening for molecules that interact with and which antagonize or agonize the anti-apoptotic properties of a pro-survival molecule. Modulators of apoptosis identified by the subject assay and compositions comprising same and their use are also contemplated herein. La présente invention concerne d'une manière générale un dosage de molécules qui modulent l'apoptose, les molécules identifiées par le dosage et l'utilisation des molécules. Plus particulièrement, un dosage est proposé pour cribler les molécules qui interagissent avec et qui produisent des effets antagonistes ou agonistes des propriétés anti-apoptotiques d'une molécule de pro-survie. L'invention concerne également les modulateurs d'apoptose identifiés par le dosage en objet et les compositions les comprenant ainsi que leur utilisation.