GLUCAGON-LIKE PEPTIDE 1(GLP-1) PHARMACEUTICAL FORMULATIONS

A composition is disclosed comprising glucagon- like peptide 1 (GLP-I) particles in combination with diketopiperazine (DKP) that is stable both in vitro and in vivo. The composition has utility as a pharmaceutical formulation for treating diseases such as diabetes, cancers, and obesity but is not li...

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Bibliographische Detailangaben
Hauptverfasser:	GELBER, COHAVA, FARIS, MARY, KING, MARK, HOKENSON, MARK, J, OBERG, KEITH, CHEATHAM, WAYMAN, WENDELL, LEONE-BAY, ANDREA, GREENE, STEPHANIE, BRANDT, DAVID
Format:	Patent
Sprache:	eng ; fre
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	A composition is disclosed comprising glucagon- like peptide 1 (GLP-I) particles in combination with diketopiperazine (DKP) that is stable both in vitro and in vivo. The composition has utility as a pharmaceutical formulation for treating diseases such as diabetes, cancers, and obesity but is not limited to such diseases or conditions. In particularly, the composition has utility as a pharmaceutical formulation for pulmonary delivery. Composition à particules de peptide apparenté au glucagon 1(GLP-1) en combinaison avec la substance dikétopipérazine (DKP) stable, à la fois in vitro et in vivo, utile comme formulation pharmaceutique pour le traitement de maladies du type diabète, cancer, et obésité, sans limitation à ces cas, et en particulier utile comme formulation pharmaceutique aux fins de délivrance pulmonaire.