QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS

The present invention relates to novel quinolones of Formula (I) that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering t...

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Bibliographische Detailangaben
Hauptverfasser:	ZHUANG, HUI, CHEN, XIAOHONG, LINDSTROM, ANDREW, K, DURON, SERGIO, G, ROPPE, JEFFREY, R, HASSIG, CHRISTIAN, A, NOBLE, STEWART, A, BONNEFOUS, CELINE, PAYNE, JOSEPH, E, SMITH, NICHOLAS, D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel quinolones of Formula (I) that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease. La présente invention concerne des quinolones innovantes de formule (I) qui inhibent la NOS-synthase inductible ainsi que des procédés de synthèse et d'utilisation des composés, y compris des procédés permettant d'inhiber ou de moduler la synthèse de l'oxyde nitrique et/ou d'abaisser le taux d'oxyde nitrique chez un patient en administrant les composés pour le traitement d'une maladie.