MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT
The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immu...
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| creator | WHITTON, STEPHEN ROBERT BUTLER, MARK STUART BUSS, ANTONY DAVID FLOTOW, HORST PHOON, CHEE, WEE XUMING, GUO KANAGASUNDARAM, YOGONATHAN MACH, BERNARD MASTERNAK, KRZYSZTOF SIM, MUI MUI TRAXLER, PETER |
| description | The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immune-related disorders and/or cancer and cancer-related disorders.
La présente invention concerne des composés macrolides, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'expression de la MHC de classe II et qui peuvent être utilisés en tant qu'agents immunosuppresseurs dans le traitement avant, pendant et/ou après une greffe d'organe ou de tissus, ainsi que dans le traitement de troubles immunitaires et/ou du cancer et de troubles liés au cancer. |
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La présente invention concerne des composés macrolides, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'expression de la MHC de classe II et qui peuvent être utilisés en tant qu'agents immunosuppresseurs dans le traitement avant, pendant et/ou après une greffe d'organe ou de tissus, ainsi que dans le traitement de troubles immunitaires et/ou du cancer et de troubles liés au cancer.</description><language>eng ; fre</language><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071004&DB=EPODOC&CC=WO&NR=2007110705A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071004&DB=EPODOC&CC=WO&NR=2007110705A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WHITTON, STEPHEN ROBERT</creatorcontrib><creatorcontrib>BUTLER, MARK STUART</creatorcontrib><creatorcontrib>BUSS, ANTONY DAVID</creatorcontrib><creatorcontrib>FLOTOW, HORST</creatorcontrib><creatorcontrib>PHOON, CHEE, WEE</creatorcontrib><creatorcontrib>XUMING, GUO</creatorcontrib><creatorcontrib>KANAGASUNDARAM, YOGONATHAN</creatorcontrib><creatorcontrib>MACH, BERNARD</creatorcontrib><creatorcontrib>MASTERNAK, KRZYSZTOF</creatorcontrib><creatorcontrib>SIM, MUI MUI</creatorcontrib><creatorcontrib>TRAXLER, PETER</creatorcontrib><title>MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT</title><description>The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immune-related disorders and/or cancer and cancer-related disorders.
La présente invention concerne des composés macrolides, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'expression de la MHC de classe II et qui peuvent être utilisés en tant qu'agents immunosuppresseurs dans le traitement avant, pendant et/ou après une greffe d'organe ou de tissus, ainsi que dans le traitement de troubles immunitaires et/ou du cancer et de troubles liés au cancer.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND2dXQO8vfxdHFVcPb3DfAP9gzx9PcLVnAMVgjxcA1yDHANDfF0VnB0d_UL4WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgYG5oaGBuYGpo5GxsSpAgAX2SXq</recordid><startdate>20071004</startdate><enddate>20071004</enddate><creator>WHITTON, STEPHEN ROBERT</creator><creator>BUTLER, MARK STUART</creator><creator>BUSS, ANTONY DAVID</creator><creator>FLOTOW, HORST</creator><creator>PHOON, CHEE, WEE</creator><creator>XUMING, GUO</creator><creator>KANAGASUNDARAM, YOGONATHAN</creator><creator>MACH, BERNARD</creator><creator>MASTERNAK, KRZYSZTOF</creator><creator>SIM, MUI MUI</creator><creator>TRAXLER, PETER</creator><scope>EVB</scope></search><sort><creationdate>20071004</creationdate><title>MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT</title><author>WHITTON, STEPHEN ROBERT ; BUTLER, MARK STUART ; BUSS, ANTONY DAVID ; FLOTOW, HORST ; PHOON, CHEE, WEE ; XUMING, GUO ; KANAGASUNDARAM, YOGONATHAN ; MACH, BERNARD ; MASTERNAK, KRZYSZTOF ; SIM, MUI MUI ; TRAXLER, PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007110705A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><toplevel>online_resources</toplevel><creatorcontrib>WHITTON, STEPHEN ROBERT</creatorcontrib><creatorcontrib>BUTLER, MARK STUART</creatorcontrib><creatorcontrib>BUSS, ANTONY DAVID</creatorcontrib><creatorcontrib>FLOTOW, HORST</creatorcontrib><creatorcontrib>PHOON, CHEE, WEE</creatorcontrib><creatorcontrib>XUMING, GUO</creatorcontrib><creatorcontrib>KANAGASUNDARAM, YOGONATHAN</creatorcontrib><creatorcontrib>MACH, BERNARD</creatorcontrib><creatorcontrib>MASTERNAK, KRZYSZTOF</creatorcontrib><creatorcontrib>SIM, MUI MUI</creatorcontrib><creatorcontrib>TRAXLER, PETER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WHITTON, STEPHEN ROBERT</au><au>BUTLER, MARK STUART</au><au>BUSS, ANTONY DAVID</au><au>FLOTOW, HORST</au><au>PHOON, CHEE, WEE</au><au>XUMING, GUO</au><au>KANAGASUNDARAM, YOGONATHAN</au><au>MACH, BERNARD</au><au>MASTERNAK, KRZYSZTOF</au><au>SIM, MUI MUI</au><au>TRAXLER, PETER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT</title><date>2007-10-04</date><risdate>2007</risdate><abstract>The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immune-related disorders and/or cancer and cancer-related disorders.
La présente invention concerne des composés macrolides, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'expression de la MHC de classe II et qui peuvent être utilisés en tant qu'agents immunosuppresseurs dans le traitement avant, pendant et/ou après une greffe d'organe ou de tissus, ainsi que dans le traitement de troubles immunitaires et/ou du cancer et de troubles liés au cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| title | MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT |
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