MACROLIDE COMPOSITIONS AS THERAPEUTIC AGENT

The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immu...

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Bibliographische Detailangaben
Hauptverfasser:	WHITTON, STEPHEN ROBERT, BUTLER, MARK STUART, BUSS, ANTONY DAVID, FLOTOW, HORST, PHOON, CHEE, WEE, XUMING, GUO, KANAGASUNDARAM, YOGONATHAN, MACH, BERNARD, MASTERNAK, KRZYSZTOF, SIM, MUI MUI, TRAXLER, PETER
Format:	Patent
Sprache:	eng ; fre
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides macrolide compounds, and pharmaceutically acceptable salts thereof, that inhibit MHC class II expression and that can be used as immunosuppressive agents in the treatment prior to, during and/or after organ or tissue transplantation, as well as in the treatment of immune-related disorders and/or cancer and cancer-related disorders. La présente invention concerne des composés macrolides, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent l'expression de la MHC de classe II et qui peuvent être utilisés en tant qu'agents immunosuppresseurs dans le traitement avant, pendant et/ou après une greffe d'organe ou de tissus, ainsi que dans le traitement de troubles immunitaires et/ou du cancer et de troubles liés au cancer.