NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel thienopyrimidine derivative having an excellent anti¬ inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to t...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, SUN-MEE, OH, BYUNG-KYU, HUH, SUNUL, WON, RAN, CHUN, KWANGWOO, KWON, HYUK-MAN, KIM, MYUNG-HWA, PARK, CHUN-HO, JOE, BO-YOUNG, CHOI, JONG-HEE, KIM, KWANG HEE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to a novel thienopyrimidine derivative having an excellent anti¬ inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-ß (IKK-ß) involved in the activation of a transcriptional factor, NF-?B, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer. L'invention porte sur un nouveau dérivé de la thiénopyrimidine présentant une excellente activité anti- inflammatoire et anti-cancéreuse ou ses dérivés pharmacocompatibles, sur son procédé de préparation, et sur des préparations pharmaceutiques les comprenant. Ce composé inhibe fortement la kinase IKB-ß (IKK-ß) impliquée dans l'activation d'un facteur de transcription, le NF-?B, associé à l'induction de différentes maladies immunes et inflammatoires; les préparations le comprenant sont donc utiles contre les maladies inflammatoires dont en particulier l'arthrite et le cancer.