FUNCTIONAL CHARACTERIZATION OF VESICULAR GLUTAMATE TRANSPORTER 2

This invention relates to the functional characterization of vesicular glutamate transporter 2 (VGLUT 2), also known as brain-specific sodium-dependent inorganic phosphate transporter (DNPI), a dominant inorganic phosphate transport system in synaptic terminals of diencephalic neurons. In particular...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CALLAERTS-VEGH, ZSUZSANNA, D'HOOGE, RUDI THEO ANGELICA, HAMPSON, RUSSELL MARK, MOECHARS, DIEDERIK WILLEM ELISABETH, MEERT, THEO FRANS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This invention relates to the functional characterization of vesicular glutamate transporter 2 (VGLUT 2), also known as brain-specific sodium-dependent inorganic phosphate transporter (DNPI), a dominant inorganic phosphate transport system in synaptic terminals of diencephalic neurons. In particular, the present invention provides evidence that VGLUT2 is associated with anxiety inducing conditions, in particular with obsessive-complusive spectrum disorders, including obsessive- compulsive disorder (OCD). La présente invention concerne la caractérisation fonctionnelle du transporteur vésiculaire du glutamate de type 2 (VGLUT 2), également appelé transporteur de phosphate inorganique sodium-dépendant spécifique au cerveau (DNPI), un système de transport du phosphate inorganique prédominant dans les terminaisons synaptiques des neurones diencéphaliques. En particulier, la présente invention démontre que le VGLUT2 est associé à des pathologies induisant de l'anxiété, en particulier à des troubles de type obsessionnel compulsif, y compris le trouble obsessionnel compulsif (TOC).