NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, P...

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Bibliographische Detailangaben
Hauptverfasser:	IRVING, BRYAN, SPARKS, MARY JEAN, RANGEL, CAROLINA, FAN, LIANGFEN, MINZE, LAURIE JEANETTE, COMBS, KATHERIN, STALA, JOY, SHI, ZHENG-ZHENG, MCLAIN, DINA REBECCA, VOGEL, PETER, TOWNSEND, TERESA GAIL, PHILLIPS, HEIDI, PAYNE, BOBBY JOE, FILVAROFF, ELLEN, WILLIS-SEVAUX, TRACY ELLEN, DESAUVAGE, FREDERIC, JUNUTULA, JAGATH REDDY, BYERS-HORNER, ALLISON ANNE, MONTGOMERY, CHARLES, A, MASSEY, ERIN MARIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. La présente invention concerne des animaux transgéniques, ainsi que des compositions et des procédés concernant la caractérisation de la fonction génique. Spécifiquement, la présente invention concerne une souris transgénique comprenant des dissociations des gènes PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 ou PRO346. Ces études et ces caractérisations in vivo permettent d'identifier et de découvrir des agents thérapeutiques et/ou des traitements de valeur utiles dans la prévention, l'amélioration ou la correction de maladies ou de dysfonctions associées à des dissociations de gènes, par exemple les troubles neurologiques ; les troubles cardiovasculaires, endothéliaux ou angiogènes ; les anomalies oculaires ; les troubles immunologiques ; les troubles oncologiques ; les anomalies ou les troubles du métabolisme osseux ; les troubles du métabolisme des lipides ; ou les anomalies développementales.