NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositio...

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Bibliographische Detailangaben
Hauptverfasser:	LANG, HENGYUAN, DAVIS, ROBERT, L, WASH, PAUL, L, GAHMAN, TIMOTHY, C, ZHAO, CUNXIANG, HERBERT, MARK, R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers. Composés et procédés utiles pour l'inhibition des protéines kinases, y compris les kinases B-Raf et plusieurs tyrosines kinases de type récepteur tyrosine et cytoplasmique. On décrit des composés d'urées pyrimidinyloxy substituées de formules II, III et IV et des compositions, et leur application comme produits pharmaceutiques pour le traitement de maladies. On décrit également des procédés de modulation d'activité de protéine kinase chez un sujet humain ou animal, pour le traitement de maladies comme le cancer.