COMPOSITIONS AND METHODS FOR PRODUCING A COMPOSITION

The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass- producing CTLA4-Ig from mammalian cells capable o...

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Bibliographische Detailangaben
Hauptverfasser:	SCHICHO, RICHARD, N, RUSSELL, REB, J, SCHAEFER, EUGENE, J, BRAMHALL, ELIZABETH, A, HOSSELET, STEPHEN, SMOLIN, DAVID, E, GRACE, MICHAEL, FLESHER, ALAN, R, THAMMANA, PALLAIAH, VELAYUDHAN, AJOY, VANDEN BOOM, THOMAS, TABOR, JOHN, M, LEISTER, KIRK, J, DONALDSON, ROBERT, TAY, LEE, K, HAGGERTY, HELEN, G, DIDIO, DAVID, M, KIRKLEY, DAVID, H, BATES, RONALD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass- producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig. L'invention concerne des cellules de mammifères capables de produire du CTLA4-Ig recombinant et des variants de celui-ci. L'invention concerne également des compositions comprenant du CTLA4-Ig et leurs formulations. L'invention concerne en outre des procédés de production en gros volume de CTLA4-Ig à partir de cellules de mammifères capables de produire cette protéine recombinante, ainsi que des procédés de purification du CTLA4-Ig.