USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs . Examples of the alpha-hydroxycarbonyl compounds used are dihydro...

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Bibliographische Detailangaben
1. Verfasser: KNOX, RICHARD, JOHN
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs . Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde , glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone. La présente invention concerne l'utilisation de composés a-hydroxycarbonyle en tant qu'agents réducteurs capables de former des dimères cycliques. La présente invention concerne également les procédés correspondants destinés à réduire des composés réductibles, en particulier des pro-médicaments activés par réduction.