METHODS FOR GENERATING AND SCREENING FUSION PROTEIN LIBRARIES AND USES THEREOF

The invention provides methods for generating fusion protein libraries, such as immuntoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of...

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Bibliographische Detailangaben
Hauptverfasser:	GLOVER, NICHOLAS, R, CIZEAU, JEANNICK, MACDONALD, GLEN, SCHWARTZ MITTELMAN, ADRIAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for generating fusion protein libraries, such as immuntoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of the libraries to screen for fusion proteins that are specific for target cells, such as cancer cells. Further, the invention relates to methods of improving fusion proteins and to the improved fusion proteins. L'invention concerne des méthodes pour générer des bibliothèques de protéines hybrides, notamment des bibliothèques de cellules recombinantes codant des séquences d'acide nucléique comprenant des protéines hybrides. En outre, l'invention concerne les bibliothèques susmentionnées et leur utilisation pour cribler des protéines hybrides spécifiques à des cellules cibles, notamment des cellules cancéreuses. En outre, l'invention concerne des méthodes d'amélioration de protéines hybrides et les protéines hybrides améliorées obtenues par cette méthode.