METHODS FOR OBTAINING OPTICALLY ACTIVE EPOXIDES AND DIOLS FROM 2,3-DISUBSTITUTED AND 2,3-TRISUBSTITUTED EPOXIDES

The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific internal epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells conta...

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Bibliographische Detailangaben
Hauptverfasser:	SIMPSON, CLINTON, BOTES, ADRIANA, LEONORA, ROTH, ROBYN, VAN DER WESTHUIZEN, CHRISTOPHER, LOTTER, JEANETTE, MITRA, ROBIN, KUMAR, LABUSCAGNE, MICHEL, ABRAHAMS, NASREEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMES ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific internal epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining optically active internal epoxides and corresponding optically active internal diols. L'invention concerne des souches de levures, ainsi que des polypeptides codés par des gènes de ces souches de levures, qui ont une activité d'époxyde hydrolase interne énantiospécifique. L'invention concerne également des molécules d'acides nucléiques codant pour ces polypeptides, des vecteurs contenant ces molécules d'acides nucléiques, ainsi que des cellules contenant ces vecteurs. L'invention concerne en outre des procédés d'obtention d'époxydes internes optiquement actifs et de diols internes optiquement actifs correspondants.