METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS

METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS

The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identificati...

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Bibliographische Detailangaben
Hauptverfasser: LABKVOSKY, BORIS, YU, LIPING, HOLZMAN, THOMAS, F, EDALJI, ROHINTON, P, PERADA-LOPEZ, ANA, HARLAN, JOHN, E, OLEJNICZAK, EDWARD, T
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays. L'invention porte sur le clonage, l'expression et l'isolement de formes recombinées de la protéine bêta-amyloïde contenant une méthionine à terminaison N (ou au moins un acide aminé de cette dernière), et sur des procédés d'utilisation de ladite protéine recombinée pour la production d'anticorps thérapeutiques, l'identification de petites molécules thérapeutiques et la mise en oeuvre de dosages diagnostiques.