NEW PLEUROMUTILIN DERIVATIVE AND ITS USE

The invention is directed to the succinate salt of trans-4-aminocyclohexyl (1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramenthyl-9-oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA). Compound IA is useful for the treatment of a variety of diseases and conditions, such...

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Bibliographische Detailangaben
Hauptverfasser:	SISKO, JOSEPH, VOGT, FREDERICK, G, DIEDERICH, ANN, MARIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention is directed to the succinate salt of trans-4-aminocyclohexyl (1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramenthyl-9-oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA). Compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA. La présente invention concerne le sel succinate du trans-4-aminocyclohexyl (1S,2R,3S,4S,6R,7R,8R,14R)-4-éthényl-3-hydroxy-2,4,7,14-tétraméthyl-9-oxotricyclo [5.4.3.01,8]tétradec-6-yl imido dicarbonate (composé IA). Le composé IA est utilisable pour le traitement de maladies et d'états variés tels que des infections des voies respiratoires et de la peau et des structures cutanées. L'invention concerne en outre le traitement d'infections des voies respiratoires et de la peau et des structures cutanées à l'aide du composé IA ou d'une composition pharmaceutique comprenant le composé IA.