MRHOS AS MODIFIERS OF THE RHO PATHWAY AND METHODS OF USE

Human MRHO genes are identified as modulators of the RHO pathway, and thus are therapeutic targets for disorders associated with defective RHO function. Methods for identifying modulators of RHO, comprising screening for agents that modulate the activity of MRHO are provided. Selon l'invention...

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Hauptverfasser:	FRANCIS, GEORGE ROSS, BJERKE, LYNN MARGARET, HEUER, TIMOTHY S, AMUNDSEN, CRAIG D, LICKTEIG, KIM, ADAMKEWICZ, JOANNE, NICOLL, MONIQUE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	Human MRHO genes are identified as modulators of the RHO pathway, and thus are therapeutic targets for disorders associated with defective RHO function. Methods for identifying modulators of RHO, comprising screening for agents that modulate the activity of MRHO are provided. Selon l'invention des gènes d'agents de modification des RHO humains sont identifiés comme des modulateurs du passage des RHO, et deviennent ainsi des cibles thérapeutiques pour des troubles associés à un défaillance des protéines RHO. L'invention concerne également des procédés pour identifier des modulateurs des RHO, comprenant le criblage d'agents qui modulent l'activité des agents de modification des RHO.