LOAD INDEPENDENT INDEX OF DIASTOLIC FUNCTION

The present invention is based in part on the surprising discovery that a load independent index of diastolic function (LIIDF) can be obtained from a determination of peak driving force (kx0) and peak-resistive force (cEpeak) in a subject, and that kxo vs. cEpeak, maintain a load independent and linear relationship Similarly, a non model-based approach using a value for duration of the E-wave (Edur) from the E-wave, and a value for a deceleration time-acceleration time (DT-AT) of the E-wave can be used to derive a linear function describing the relationship of Edur to DT-AT, which also provides the analogous LIIDF The LIIDF can be obtained using data obtained from a variety of imaging modalities, including noninvasive and invasive modalities. La présente invention concerne des procédés, ainsi que des appareils et systèmes correspondants, permettant de déterminer, indépendamment de la charge, un indice de fonction diastolique dans le coeur.