PROCESS FOR INDUSTRIALLY VIABLE PREPARATION OF IMIDAPRIL HYDROCHLORIDE

PROCESS FOR INDUSTRIALLY VIABLE PREPARATION OF IMIDAPRIL HYDROCHLORIDE

The invention relates to a novel method for the preparation of imidapril hydrochloride of formula-l by reacting esters of 4(S)-1-methyl-2-oxoimidazolidine-4-carboxylate of formula-ll with (S)-ethyl-2-[(S)-4-methyl-2,5-dioxooxazolidin-3-yl]-4-phenylbutanoate of formula-Ill and hydrolyzing the coupled...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: POTLURI, RAMESH, BABU, VENKATA SUBRAMANIAN, HARIHARAKRISHNAN, KODALI, HARI, PRASAD
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a novel method for the preparation of imidapril hydrochloride of formula-l by reacting esters of 4(S)-1-methyl-2-oxoimidazolidine-4-carboxylate of formula-ll with (S)-ethyl-2-[(S)-4-methyl-2,5-dioxooxazolidin-3-yl]-4-phenylbutanoate of formula-Ill and hydrolyzing the coupled product with an alcoholic hydrochloride. La présente invention concerne un procédé innovant de préparation de chlorhydrate d'imidapril de formule (I). Selon ledit procédé, on fait réagir des esters de 4-carboxylate de 4(S)-1-méthyl-2-oxoimidazolidine de formule (II) avec du 4-phénylbutanoate de (S)-éthyl-2-[(S)-4-méthyl-2,5-dioxooxazolidin-3-yl] de formule (III) et on hydrolyse le produit couplé avec un chlorhydrate alcoolique.