SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV

The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disea...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CHAKLADAR, SASWATI, MUTHUKAMAL, NAGARAJAN, RAY, ABHIJIT, DASTIDAR, SUNANDA G, BALACHANDRAN, SARALA, BAREGAMA, LALIT KUMAR, PALLE, VENAKTA, RAMNANI, SARIKA
Format: Patent
Sprache:eng ; fre
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator CHAKLADAR, SASWATI
MUTHUKAMAL, NAGARAJAN
RAY, ABHIJIT
DASTIDAR, SUNANDA G
BALACHANDRAN, SARALA
BAREGAMA, LALIT KUMAR
PALLE, VENAKTA
RAMNANI, SARIKA
description The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS) , eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia) L'invention concerne des dérivés d'isoxazoline de structure (Ia), pouvant être utilisés en tant qu'inhibiteurs sélectifs de phosphodiestérase (PDE) de type IV. Ls composés de l'invention peuvent être utiles dans le traitement des maladies et troubles suivants : troubles du SNC, SIDA, asthme, arthrite, bronchite, bronchopneumopathie chronique obstructive (BPCO), psoriasis, rhinite allergique, choc, dermatite atopique, maladie de Crohn, syndrome de détresse respiratoire de l'adulte (SDRA), granulome éosinophile des os, conjonctivite allergique, ostéoarthrite, rectocolite hémorragique et autres maladies inflammatoires en particulier chez l'être humain. L'invention concerne également des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant, et leur utilisation en tant qu'inhibiteurs de phosphodiestérase (PDE) de type IV.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2007029077A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2007029077A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2007029077A13</originalsourceid><addsrcrecordid>eNrjZHAIDnUKDvEMCQ1xdVHw9HNxjPL3cQ1WcAwGcjw8nTxD_IOCFfzdFAI8_IOB2MXTNTjENcgx2FUhJDLAVdczjIeBNS0xpziVF0pzMyi7uYY4e-imFuTHpxYXJCan5qWWxIf7GxkYmBsYWRqYmzsaGhOnCgCcQywg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV</title><source>esp@cenet</source><creator>CHAKLADAR, SASWATI ; MUTHUKAMAL, NAGARAJAN ; RAY, ABHIJIT ; DASTIDAR, SUNANDA G ; BALACHANDRAN, SARALA ; BAREGAMA, LALIT KUMAR ; PALLE, VENAKTA ; RAMNANI, SARIKA</creator><creatorcontrib>CHAKLADAR, SASWATI ; MUTHUKAMAL, NAGARAJAN ; RAY, ABHIJIT ; DASTIDAR, SUNANDA G ; BALACHANDRAN, SARALA ; BAREGAMA, LALIT KUMAR ; PALLE, VENAKTA ; RAMNANI, SARIKA</creatorcontrib><description>The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS) , eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia) L'invention concerne des dérivés d'isoxazoline de structure (Ia), pouvant être utilisés en tant qu'inhibiteurs sélectifs de phosphodiestérase (PDE) de type IV. Ls composés de l'invention peuvent être utiles dans le traitement des maladies et troubles suivants : troubles du SNC, SIDA, asthme, arthrite, bronchite, bronchopneumopathie chronique obstructive (BPCO), psoriasis, rhinite allergique, choc, dermatite atopique, maladie de Crohn, syndrome de détresse respiratoire de l'adulte (SDRA), granulome éosinophile des os, conjonctivite allergique, ostéoarthrite, rectocolite hémorragique et autres maladies inflammatoires en particulier chez l'être humain. L'invention concerne également des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant, et leur utilisation en tant qu'inhibiteurs de phosphodiestérase (PDE) de type IV.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20070315&amp;DB=EPODOC&amp;CC=WO&amp;NR=2007029077A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20070315&amp;DB=EPODOC&amp;CC=WO&amp;NR=2007029077A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAKLADAR, SASWATI</creatorcontrib><creatorcontrib>MUTHUKAMAL, NAGARAJAN</creatorcontrib><creatorcontrib>RAY, ABHIJIT</creatorcontrib><creatorcontrib>DASTIDAR, SUNANDA G</creatorcontrib><creatorcontrib>BALACHANDRAN, SARALA</creatorcontrib><creatorcontrib>BAREGAMA, LALIT KUMAR</creatorcontrib><creatorcontrib>PALLE, VENAKTA</creatorcontrib><creatorcontrib>RAMNANI, SARIKA</creatorcontrib><title>SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV</title><description>The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS) , eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia) L'invention concerne des dérivés d'isoxazoline de structure (Ia), pouvant être utilisés en tant qu'inhibiteurs sélectifs de phosphodiestérase (PDE) de type IV. Ls composés de l'invention peuvent être utiles dans le traitement des maladies et troubles suivants : troubles du SNC, SIDA, asthme, arthrite, bronchite, bronchopneumopathie chronique obstructive (BPCO), psoriasis, rhinite allergique, choc, dermatite atopique, maladie de Crohn, syndrome de détresse respiratoire de l'adulte (SDRA), granulome éosinophile des os, conjonctivite allergique, ostéoarthrite, rectocolite hémorragique et autres maladies inflammatoires en particulier chez l'être humain. L'invention concerne également des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant, et leur utilisation en tant qu'inhibiteurs de phosphodiestérase (PDE) de type IV.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAIDnUKDvEMCQ1xdVHw9HNxjPL3cQ1WcAwGcjw8nTxD_IOCFfzdFAI8_IOB2MXTNTjENcgx2FUhJDLAVdczjIeBNS0xpziVF0pzMyi7uYY4e-imFuTHpxYXJCan5qWWxIf7GxkYmBsYWRqYmzsaGhOnCgCcQywg</recordid><startdate>20070315</startdate><enddate>20070315</enddate><creator>CHAKLADAR, SASWATI</creator><creator>MUTHUKAMAL, NAGARAJAN</creator><creator>RAY, ABHIJIT</creator><creator>DASTIDAR, SUNANDA G</creator><creator>BALACHANDRAN, SARALA</creator><creator>BAREGAMA, LALIT KUMAR</creator><creator>PALLE, VENAKTA</creator><creator>RAMNANI, SARIKA</creator><scope>EVB</scope></search><sort><creationdate>20070315</creationdate><title>SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV</title><author>CHAKLADAR, SASWATI ; MUTHUKAMAL, NAGARAJAN ; RAY, ABHIJIT ; DASTIDAR, SUNANDA G ; BALACHANDRAN, SARALA ; BAREGAMA, LALIT KUMAR ; PALLE, VENAKTA ; RAMNANI, SARIKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007029077A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAKLADAR, SASWATI</creatorcontrib><creatorcontrib>MUTHUKAMAL, NAGARAJAN</creatorcontrib><creatorcontrib>RAY, ABHIJIT</creatorcontrib><creatorcontrib>DASTIDAR, SUNANDA G</creatorcontrib><creatorcontrib>BALACHANDRAN, SARALA</creatorcontrib><creatorcontrib>BAREGAMA, LALIT KUMAR</creatorcontrib><creatorcontrib>PALLE, VENAKTA</creatorcontrib><creatorcontrib>RAMNANI, SARIKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAKLADAR, SASWATI</au><au>MUTHUKAMAL, NAGARAJAN</au><au>RAY, ABHIJIT</au><au>DASTIDAR, SUNANDA G</au><au>BALACHANDRAN, SARALA</au><au>BAREGAMA, LALIT KUMAR</au><au>PALLE, VENAKTA</au><au>RAMNANI, SARIKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV</title><date>2007-03-15</date><risdate>2007</risdate><abstract>The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS) , eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia) L'invention concerne des dérivés d'isoxazoline de structure (Ia), pouvant être utilisés en tant qu'inhibiteurs sélectifs de phosphodiestérase (PDE) de type IV. Ls composés de l'invention peuvent être utiles dans le traitement des maladies et troubles suivants : troubles du SNC, SIDA, asthme, arthrite, bronchite, bronchopneumopathie chronique obstructive (BPCO), psoriasis, rhinite allergique, choc, dermatite atopique, maladie de Crohn, syndrome de détresse respiratoire de l'adulte (SDRA), granulome éosinophile des os, conjonctivite allergique, ostéoarthrite, rectocolite hémorragique et autres maladies inflammatoires en particulier chez l'être humain. L'invention concerne également des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant, et leur utilisation en tant qu'inhibiteurs de phosphodiestérase (PDE) de type IV.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre
recordid cdi_epo_espacenet_WO2007029077A1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SUBSTITUTED INDAZOLES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T14%3A14%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHAKLADAR,%20SASWATI&rft.date=2007-03-15&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2007029077A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true