A NOVEL PROCESS FOR PREPARATION OF HIGHLY PURE CRYSTALLINE HYDROCHLOROTHIAZIDE

A NOVEL PROCESS FOR PREPARATION OF HIGHLY PURE CRYSTALLINE HYDROCHLOROTHIAZIDE

This invention relates to a process for the preparation and purification of a pure crystalline Hydrochlorothiazide with overall purity 99.9% or greater and single impurity below 0.1%. This is a two step process. In first step crude hydrochlorothiazide is prepared which is in second step purified to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SINGARE, DNYANESHWAR, TUARAM, KUMAR, NEERAJ, RAMAKRISHNAN, ARUL, KAPKOTI, GOBIND, SINGH
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention relates to a process for the preparation and purification of a pure crystalline Hydrochlorothiazide with overall purity 99.9% or greater and single impurity below 0.1%. This is a two step process. In first step crude hydrochlorothiazide is prepared which is in second step purified to get highly pure crystalline hydrochlorothiazide. L'invention concerne un procédé de préparation et de purification d'hydrochlorothiazide cristallin pur avec une pureté globale de 99,9% ou plus et une impureté inférieure à 0,1%. Ledit procédé comprend deux étapes. L'hydrochlorothiazide brut est préparé au cours d'une première étape, puis purifié au cours d'une seconde étape pour obtenir un hydrochlorothiazide cristallin d'une grande pureté.