NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provide...

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Hauptverfasser: SIDDIQUI, M. ARSHAD, HRUZA, ALAN, W, MAYHOOD, TODD, W, SHIPPS, GERALD W., JR, LEES, EMMA, M, POPOVICI-MULLER, JANETA, MCNEMAR, CHARLES, WAYNE, ZHAO, LIANYUN, MADISON, VINCENT, S, FISCHMANN, THIERRY, O, WINDSOR, WILLIAM, T, PARRY, DAVID, A, DUCA, JOSE, S, DENG, YONGQI, CURRAN, PATRICK, J, ZHANG, RUMIN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms. L'invention concerne des inhibiteurs de la kinase 2 dépendant des cyclines à base de quinoline, des compositions comprenant ces inhibiteurs et des procédés d'utilisation des inhibiteurs et des compositions d'inhibiteurs. Ces inhibiteurs et les compositions comprenant ceux-ci sont utiles pour traiter une maladie ou des symptômes pathologiques. L'invention concerne aussi des procédés de fabrication de composés d'inhibiteurs de la CDK-2, de procédés d'inhibition de la CDK-2 et des méthodes de traitement d'une maladie ou de symptômes pathologiques.