MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE

MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE

The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LANCET, DORON, GROSSMAN, IRIS, GOLDSTAUB, DAN, SINGER, CLARA, AVIDAN, NILI, HAYARDENY, LIAT, MILLER, ARIEL, BECKMANN, JACQUES, BEN-ASHER, EDNA
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl and IL-12RB2. La présente invention concerne des procédés et des kits basés, au moins en partie, sur l'identification de la sensibilité ou non sensibilité allèle-spécifique à l'acétate de glatiramère pour le traitement de troubles de l'immunité tels que la sclérose en plaques cyclique. La sensibilité ou non sensibilité allèle-spécifique à l'acétate de glatiramère se base sur des polymorphismes des gènes suivants: CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl et IL-12RB2.