DETECTION OF AN IMMUNE RESPONSE TO GDF-8 MODULATING AGENTS

This disclosure provides methods for the detection of antibodies to a GDF-8 modulating agent such as, e.g., MYO-029, in a biological sample. Methods to detect an immune response to a GDF-8 modulating agent are also included. In particular, methods to assess an immune response in animals, including h...

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Bibliographische Detailangaben
Hauptverfasser:	CAIAZZO, TERESA M, SUN, SHUJUN, O'HARA, DENISE M, RAJEWSKI, JOSEPH W. III, CRYAN, JOHN G, JOYCE, ALISON, NOWAK, JOHN A, WOLFMAN, NEIL M
Format:	Patent
Sprache:	eng ; fre
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Zusammenfassung:	This disclosure provides methods for the detection of antibodies to a GDF-8 modulating agent such as, e.g., MYO-029, in a biological sample. Methods to detect an immune response to a GDF-8 modulating agent are also included. In particular, methods to assess an immune response in animals, including humans, to a GDF-8 modulating agent such as a GDF-8 inhibitor are provided herein. L'invention concerne des procédés de détection d'anticorps contre un agent de modulation GDF-8, par exemple, le MYO-029, dans un prélèvement biologique. De plus, l'invention concerne des procédés de détection d'une réponse immunitaire contre un agent de modulation GDF-8. En particulier, l'invention concerne des procédés d'évaluation d'une réponse immunitaire chez les animaux, y compris les humains, contre un agent de modulation GDF-8, tel que l'inhibiteur GDF-8.