4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS

4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compos...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ENNIS, MICHAEL, DALTON, KORTUM, STEVEN, WADE, TENBRINK, RUTH, ELIZABETH
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. L'invention concerne des composés et des sels de ceux-ci acceptables sur le plan pharmaceutique, ces composés possédant une structure de formule (I), dans laquelle A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5 et R6 sont tels que définis dans la description détaillée de l'invention. L'invention concerne également des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse et des intermédiaires.