BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION
Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m. L'invention conce...
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| creator | COMPTON, TERESA ENGLISH, EMILY, P GELLMAN, SAMUEL, H CHUMANOV, ROBERT, S |
| description | Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m.
L'invention concerne des bêta-polypeptides imitant les régions d'enroulements spiralés de gB et gH par présentation des restes hydrophobes clés pour une concentration d'enroulements spiralés sur une face de l'hélice-12 des bêta-polypeptides. L'inhibiteur le plus puissant bloque l'infection du CMV avec un IC50 d'approximativement 20 m. |
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L'invention concerne des bêta-polypeptides imitant les régions d'enroulements spiralés de gB et gH par présentation des restes hydrophobes clés pour une concentration d'enroulements spiralés sur une face de l'hélice-12 des bêta-polypeptides. L'inhibiteur le plus puissant bloque l'infection du CMV avec un IC50 d'approximativement 20 m.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070329&DB=EPODOC&CC=WO&NR=2006099170A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070329&DB=EPODOC&CC=WO&NR=2006099170A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COMPTON, TERESA</creatorcontrib><creatorcontrib>ENGLISH, EMILY, P</creatorcontrib><creatorcontrib>GELLMAN, SAMUEL, H</creatorcontrib><creatorcontrib>CHUMANOV, ROBERT, S</creatorcontrib><title>BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION</title><description>Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m.
L'invention concerne des bêta-polypeptides imitant les régions d'enroulements spiralés de gB et gH par présentation des restes hydrophobes clés pour une concentration d'enroulements spiralés sur une face de l'hélice-12 des bêta-polypeptides. L'inhibiteur le plus puissant bloque l'infection du CMV avec un IC50 d'approximativement 20 m.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBwcg1x1A3w94kMcA0I8XRxDVYI8XAMUfD08_B08gxRcI4M8fd1dXf08Q_zDAoNBoq7uTqHePr78TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMDMwNLS0NzA0djY-JUAQA9Finm</recordid><startdate>20070329</startdate><enddate>20070329</enddate><creator>COMPTON, TERESA</creator><creator>ENGLISH, EMILY, P</creator><creator>GELLMAN, SAMUEL, H</creator><creator>CHUMANOV, ROBERT, S</creator><scope>EVB</scope></search><sort><creationdate>20070329</creationdate><title>BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION</title><author>COMPTON, TERESA ; ENGLISH, EMILY, P ; GELLMAN, SAMUEL, H ; CHUMANOV, ROBERT, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006099170A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>COMPTON, TERESA</creatorcontrib><creatorcontrib>ENGLISH, EMILY, P</creatorcontrib><creatorcontrib>GELLMAN, SAMUEL, H</creatorcontrib><creatorcontrib>CHUMANOV, ROBERT, S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>COMPTON, TERESA</au><au>ENGLISH, EMILY, P</au><au>GELLMAN, SAMUEL, H</au><au>CHUMANOV, ROBERT, S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION</title><date>2007-03-29</date><risdate>2007</risdate><abstract>Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m.
L'invention concerne des bêta-polypeptides imitant les régions d'enroulements spiralés de gB et gH par présentation des restes hydrophobes clés pour une concentration d'enroulements spiralés sur une face de l'hélice-12 des bêta-polypeptides. L'inhibiteur le plus puissant bloque l'infection du CMV avec un IC50 d'approximativement 20 m.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION |
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