BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION

BETA-POLYPEPTIDES THAT INHIBIT CYTOMEGALOVIRUS INFECTION

Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m. L'invention conce...

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Bibliographische Detailangaben
Hauptverfasser: COMPTON, TERESA, ENGLISH, EMILY, P, GELLMAN, SAMUEL, H, CHUMANOV, ROBERT, S
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m. L'invention concerne des bêta-polypeptides imitant les régions d'enroulements spiralés de gB et gH par présentation des restes hydrophobes clés pour une concentration d'enroulements spiralés sur une face de l'hélice-12 des bêta-polypeptides. L'inhibiteur le plus puissant bloque l'infection du CMV avec un IC50 d'approximativement 20 m.