NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE
The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions...
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| creator | BRIMERT, THOMAS SANDMARK, JENNY LOENN, HANS LAWITZ, KAROLINA RAY, ASIM, KUMAR NIKITIDIS, ANTONIOS |
| description | The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
L'invention concerne de des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R14, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase. |
| format | Patent |
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L'invention concerne de des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R14, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060921&DB=EPODOC&CC=WO&NR=2006098684A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060921&DB=EPODOC&CC=WO&NR=2006098684A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRIMERT, THOMAS</creatorcontrib><creatorcontrib>SANDMARK, JENNY</creatorcontrib><creatorcontrib>LOENN, HANS</creatorcontrib><creatorcontrib>LAWITZ, KAROLINA</creatorcontrib><creatorcontrib>RAY, ASIM, KUMAR</creatorcontrib><creatorcontrib>NIKITIDIS, ANTONIOS</creatorcontrib><title>NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE</title><description>The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
L'invention concerne de des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R14, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4FzIVYpdYzNlRzEXEjSiFMpEifRQn1_dPABnP7h-5cFW05ooOWz496qAERQle7qSZFFUOgpyUgJA8gvWk0niuwDcAcW--jZaTIIaGSIMuC6WNzHx5w3v66KbYex1WWeXkOep_GWn_k9XLgSohbHpm4Ocrf_7_oAFv4v-A</recordid><startdate>20060921</startdate><enddate>20060921</enddate><creator>BRIMERT, THOMAS</creator><creator>SANDMARK, JENNY</creator><creator>LOENN, HANS</creator><creator>LAWITZ, KAROLINA</creator><creator>RAY, ASIM, KUMAR</creator><creator>NIKITIDIS, ANTONIOS</creator><scope>EVB</scope></search><sort><creationdate>20060921</creationdate><title>NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE</title><author>BRIMERT, THOMAS ; SANDMARK, JENNY ; LOENN, HANS ; LAWITZ, KAROLINA ; RAY, ASIM, KUMAR ; NIKITIDIS, ANTONIOS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006098684A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRIMERT, THOMAS</creatorcontrib><creatorcontrib>SANDMARK, JENNY</creatorcontrib><creatorcontrib>LOENN, HANS</creatorcontrib><creatorcontrib>LAWITZ, KAROLINA</creatorcontrib><creatorcontrib>RAY, ASIM, KUMAR</creatorcontrib><creatorcontrib>NIKITIDIS, ANTONIOS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRIMERT, THOMAS</au><au>SANDMARK, JENNY</au><au>LOENN, HANS</au><au>LAWITZ, KAROLINA</au><au>RAY, ASIM, KUMAR</au><au>NIKITIDIS, ANTONIOS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE</title><date>2006-09-21</date><risdate>2006</risdate><abstract>The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
L'invention concerne de des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R14, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE |
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