NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE

The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser:	BRIMERT, THOMAS, SANDMARK, JENNY, LOENN, HANS, LAWITZ, KAROLINA, RAY, ASIM, KUMAR, NIKITIDIS, ANTONIOS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. L'invention concerne de des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R14, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase.